Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

The term 'autophagy' was chosen to distinguish the lysosomal degradation ... to analyse mammalian cells that express autophagy proteins tagged with fluorescent markers. Time-lapse studies provide ...

The autophagy process degrades and recycles malformed proteins or worn-out organelles using lysosomal machinery. In the past, autophagy has been shown to act only as an adaptive response to extreme ...

which are linked to imbalances in lipid and protein production and degradation. Furthermore, improving autophagy function has the potential to slow cellular ageing by preserving organelle quality ...

And it also degrades and recycles proteins when cells become starved. As a result, it plays a role in maintaining the constant environment in the living body. *2 selective autophagy Traditionally, ...

Intracellular constituents such as proteins and organelles are turned over by unremitting synthesis and degradation. This dynamic turnover is critical for homeostasis, development, and environmental ...

Metastatic progression is driven by the expression and stabilization of pro-metastatic proteins. This study reveals how ...

which are linked to imbalances in lipid and protein production and degradation. Furthermore, improving autophagy function has the potential to slow cellular aging by preserving organelle quality ...

Guan and his team compared 171 genes that influence autophagy to study how they affect metastasis in a mouse model of breast cancer. By using clustered regulatory interspaced palindromic repeats ...

My group focuses on understanding cell signaling pathways primarily linked with the ubiquitin and autophagy systems and frequently ... ubiquitylation, protein translation, degradation, and trafficking ...