A rare cell in the lining of lungs is fundamental to the organ-wide response necessary to repair damage from toxins like ...

It is from these cells, which express a gene called Krt5 that helps to build the structure of cells, that lung squamous cell carcinoma (LUSC) eventually develops.

Lung cancer remains the world’s deadliest cancer, and cigarette smoke is its chief culprit. Chemicals in tobacco, such as polycyclic aromatic hydrocarbons (PAHs), damage DNA and trigger the mutations ...

Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells. Cell Stem Cell , 2023; DOI: 10.1016/j.stem.2023.07.014 ...

Image of a lung lobe from a carcinogen-exposed mouse. Cells expressing the basal cell marker KRT5 have been fluorescently labelled and can be seen spreading throughout the bronchial tree Credit ...

A new study found that deleting a gene called KMT2D caused normal (basal) lung cells grown in complex cultures called organoids to transform into lung squamous carcinoma (LUSC) cells.

Basaloid: These cancer cells resemble the basal cells found in the deepest layers of the lung epithelium, and tend to be arranged in lobules. Signs and Symptoms of Squamous Cell Lung Cancer ...

Researchers in Japan have successfully generated lung cells similar to alveolar epithelial type 2 (AT2) cells from mouse ...