Measuring the GATA1 and PU.1 proteins in single cells enabled the researchers to see that those proteins are not central players in blood cell differentiation. "For decades it was thought that these ...

Epigenetic mechanisms of blood cell differentiation Date: May 20, 2020 Source: Max Planck Institute of Immunobiology and Epigenetics Summary: In the bone marrow, blood stem cells via precursor ...

Every second, an adult generates around five million new blood cells to replace aging or dying ones, ... Continuous map of early hematopoietic stem cell differentiation across human lifetime.

The development of mature blood cells from haematopoietic stem cells has long served as a model for stem-cell research, with the haematopoietic differentiation tree being widely used as a model ...

Endothelial cells with properties of cord-blood endothelial colony-forming cells are generated from human pluripotent stem cells. The ability to differentiate human pluripotent stem cells into ...

In blood stem cell differentiation, single-cell transcriptomics and imaging-based studies have demonstrated that key TFs are expressed in smooth, ...

Each represents a different stage in the differentiation process of blood cells; stem cells can become any kind of blood cell, progenitor cells are already on a particular track and granulocytes ...

More specifically, they captured “hundreds of clonal differentiation trajectories across tens of individuals and 230,358 single cells.” In young blood, thousands of different stem cells ...

A breakthrough in the understanding of how mammals create red blood cells could lead to opportunities for artificial blood to ...

Our blood consists of many cell types that develop through different stages from a precursor type -- the blood stem cell. An international research team led by Universitätsmedizin Frankfurt and ...

Interestingly, all of these cells undergo a multi-level differentiation process called erythropoiesis. ... On average, the human body contains 35 trillion red blood cells (RBCs).