Three major pathways to apoptosis-associated caspase activation have been identified in mammals: the extrinsic or death receptor pathway, the intrinsic or apoptosome pathway and the cytotoxic ...

Khwaja A, Tatton L . 1999 Resistance to the cytotoxic effects of tumor necrosis factor alpha can be overcome by inhibition of a FADD/Caspase-dependent signaling pathway J. Biol. Chem. 274: 36817 ...

By creating artificial aging in mice, researchers at Lund University in Sweden have been able to track the formation of ...

Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease ...

Our studies suggest that Caspase-8 does so by activating the MAPK pathway through Src. ... This suggests that Caspase-8 mediates signaling through the RXDLL domain.

Scientists discover a new signaling pathway and design a novel drug for liver fibrosis. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2024 / 04 / 240426110048.htm ...

Apoptosis is an important cellular process that allows cells to die in a programmed fashion, essential for embryo development, homeostasis, and cancer development. This 3D animation provides an ...

A recent research finding adds to evidence that brain inflammation is a major driver of neurodegenerative disorders such as ...

Their deregulation can underlie many human diseases and a number of caspases, particularly caspase-2, have been reported to have tumor suppressor functions. Emerging evidence suggests that caspases do ...