Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...
The ubiquitinated substrate can then perform multiple functions, including cell cycle, proliferation, differentiation, DNA repair, energy metabolism, signal transduction and immune regulation, etc.
The N-terminal p50 with transcription activity enters the nucleus to activate the expression of ER stress and ERAD genes, such as GRP78/BiP ... while the GRP78 promoter containing classical ERSE sites ...
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