The duration of expression of the gene Cdx2 is tightly regulated by a newly identified DNA sequence element called an “attenuator.” ...

Regulatory sequences of DNA -- motifs called enhancers and promoters -- bind to transcription factors to regulate the expression of target genes at a specific time and place.

Unlocking the Potential of Minicircle DNA A fully synthetic, cell-free approach to mcDNA production could unlock new possibilities for safer, more efficient gene therapy.

Principles and patterns of nucleosome positioning have emerged through recent advances in genome-wide mapping technologies. These patterns have improved understanding of how DNA sequence and ...

There is no discernable significant homology between human and either chicken or zebrafish insulin promoters, which is in keeping with the view that most human DNA is not alignable to species ...

ChIP assays using MIN6 ß-cells have shown that PDX-1, MafA, E47, and ß2 bind to the mouse insulin 2 promoter in a cyclical manner with a periodicity of ~10–15 min. [125] Insulin gene ...

Our cells' identity is shaped by DNA tags called methylation. New tech, scDEEP-mC, maps these tags in single cells with ...