This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...

[101] This sequence, which is known to induce DNA curvature, may serve to bring together proteins that bind at sites flanking this motif. Examination of the other insulin promoters reveals that ...

The study comprehensively analyzed "cis-regulatory elements" (CREs), which are the DNA sequences ... including enhancers and promoters, are essential for controlling when and where genes are ...

In addition, we discuss emerging research implicating HSF1’s roles in autophagy, apoptosis, DNA damage repair ... by acting as a transcription factor of multiple autophagy-related genes (ATG), such as ...

More information: Elina Wiechens et al, Gene regulation by convergent promoters, Nature Genetics (2025). DOI: 10.1038/s41588-024-02025-w Journal information: Nature Genetics ...

The numbers of the principal regulatory elements present in insulin promoters are listed. Given the complexity and uncertainty of predicting the transcriptional outcome of mutations within ...

These genes are referred to as tumor suppressor genes which code for proteins that control the repair of damaged DNA (or the elimination of the cell with damaged DNA if repair is not possible).

Epigenetics refers to heritable changes in gene expression that do not involve alterations in the underlying DNA sequence. The core epigenetic mechanisms are DNA methylation, histone modifications, ...

Proteo-Science Center, Ehime University, 2-5 Bunkyo, Matsuyama, Ehime 790-8577, Japan ...

And third, the promoter should be insulated from surrounding DNA by including extra DNA before it to further reduce leakiness. When introducing genes into yeast to make it produce drugs and other ...