The endoplasmic reticulum (ER) has a central role in mounting effective and durable antitumour immunity. In this Review, Hwang et al. outline how tumour-induced ER stress responses alter the ...

Boosting ferroptosis to defeat cancer cells Having discovered the role of EMCSs in ferroptosis, the researchers found that disrupting the physical link between the endoplasmic reticulum and ...

The intestinal epithelium is susceptible to heat stress (HS), which leads to gut leakage and inflammation. However, the mechanisms underlying HS-induced intestine dysfunction have yet to be elucidated ...

Adipocyte-hepatocyte signaling mechanism uncovered in endoplasmic reticulum stress response The endoplasmic reticulum (ER) is the portion of the cell responsible for manufacturing and folding ...

So, to identify where ferroptosis begins, our team developed a way to visualize lipid radicals in a cell." The team discovered that peroxidation of lysosomes plays a key role in the execution of ...

Fe 3 O 4 @PDA@Ru synergistically inhibited tumor growth and activated ferroptosis and endoplasmic reticulum (ER) stress by inactivation of glutathione peroxidase 4 (GPX4), consumption of glutathione ...

Sesn2 (Sestrin2) is a stress‐induced protein that provides protective effects during myocardial ischemia and reperfusion (I/R) injury, while endoplasmic reticulum (ER) stress may be a pivotal mediator ...

Department of Neurosurgery, General Hospital of Northern Theater Command, Shenyang, Liaoning, China Objective: This study aims to investigate the inhibitory effect of Polydatin (PD) on endoplasmic ...

Mechanistically, CPI-613 induces endoplasmic reticulum (ER) stress and triggers the expression level of XBP1s, which transcriptionally suppresses the expression of THBS2 gene. In addition, THBS2 ...

Discovered over a decade ago, ferroptosis is a form of non-apoptotic cell death that depends on the production of reactive oxygen species (ROS), iron and lipid peroxidation. Ferroptosis has been a ...

In a groundbreaking review titled "The Mechanism of Ferroptosis and its Related Diseases," Feng and his colleagues from the Department of Urology and the Institute of Urology, State Key ...