This study is committed to searching for inhibitors of deacetylase SIRT2 within the natural product database via computer-aided drug design techniques. A comprehensive computer-aided drug design ...

Millions of individuals rely on effective medications to manage diseases like cancer and diabetes. For those with chronic myeloid leukemia (CML), advancements in treatment selection could ...

Researchers from the Nagoya University Graduate School of Medicine identified an enzyme, alpha-kinase 2 (ALPK2) that is ...

Obesity is a significant global health challenge, linked to an increased risk of conditions like diabetes, heart disease, and ...

especially as another protease (angiotensin-converting enzyme) acting in the same biochemical pathway is the target of extremely successful protease inhibitor drugs 108. An interesting challenge ...

Several clinical trials investigate the efficacy of GEM in combination with targeted drugs, including kinase inhibitors, but the experimental evidence for such rationale is often unclear. Here, we ...

Weight-loss drugs like Ozempic may decrease your risk of developing 42 health conditions, but increase your chance of experiencing 19 others, according to one of the most comprehensive studies-of ...

Get Instant Summarized Text (Gist) The enzyme Glucose-6-phosphatase 2 (G6PC2) plays a crucial role in regulating blood sugar by influencing glucagon secretion in pancreatic α cells. Genetic ...

With further refinement, the enzyme could be adapted for even more complex reactions, making it a valuable tool in drug development, agricultural chemicals, and materials science. “The possibilities ...

Drugmakers raised the list prices on 575 name-brand drugs in just the first two days of the new year, according to drug price research firm 46brooklyn. Drugs for diabetes, HIV, cancer saw price ...

Harry Sumnall receives funding from public grant awarding bodies for alcohol and other drugs research, and fees from (international) not-for-profit organisations and government departments for ...

Traditional small-molecule inhibitor drugs typically jam a protein’s function like a ... which mark other proteins for degradation. An unfoldase enzyme in the cap pulls proteins into the cylinder, ...