Researchers tagged mouse RNA with the enzyme that makes fireflies glow, in hopes of better understanding how viruses and ...

DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...

Exploring the combination with azacitidineStudy led by Medical College of Wisconsin MADRID and CAMBRIDGE, Mass., Jan. 23, 2025 (GLOBE NEWSWIRE) -- (ISIN Code: ES0167733015, ORY), a clinical-stage ...

Traditional therapies target one molecule in the tumor microenvironment, but the microenvironment is so complex, targeting one thing doesn't always work. For example, the most well-known of these ...

Announcing a new publication for Acta Materia Medica journal. Epithelial cell adhesion molecule (EpCAM) is a biomarker for epithelial cell-derived tumors. However, the specific role of EpCAM ...

Attempts to design small molecule therapies directed to this cytokine have not led to approved products yet. Here we report the discovery and development of a potent small molecule inhibitor of TNF ...

As humans do not synthesize dTDP-l-rhamnose, the four enzymes of its metabolic pathway represent very appealing targets against which new drugs might be designed. Analysis of V. cholerae mutants ...

The system uses a degrader molecule that acts like a pair of handcuffs. One cuff links to the enzyme that normally marks defective and damaged proteins for destruction. The other cuff links to a ...

The anti-Trump posters, which depict the president-elect with the words “Keep DC trash free,” initially appeared to be created as transit ads funded by the district’s government and were ...

School of Food Science and Technology, Jiangnan University, Wuxi 214122, People’s Republic of China ...

Martinez-Bailen et al. (2020) synthesized multimeric pyrrolidine iminosugars as inhibitors of important therapeutic enzymes, human β-glucocerebrosidase (GCase) and α-galactosidase A (α-Gal A), and ...