The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution ...

Our bodies have to sense our environment, and receptors are one part of the sensory experience of the body. Receptors, such as those in taste buds... | Cell And Molecular Biology ...

Nicotinic receptors — a family of ligand-gated ion channels that mediate the effects of the neurotransmitter acetylcholine — are among the most well understood allosteric membrane proteins ...

Molecular glues, tiny molecules that connect one protein to another, are promising targets for pharmaceutical research. By ...

Using artificial intelligence, researchers show how γ-secretase recognizes substrates - an important advance for fundamental ...

A brand new biotech – Neurosterix – has been formed to take forward neuroscience programmes that originated at Switzerland’s Addex Therapeutics, including a drug for schizophrenia ...

Cerevel’s clinical pipeline also includes darigabat, an α2/3/5-selective GABAA receptor PAM currently under in a phase 2a proof-of-concept trial in epilepsy and panic disorder, due to read out ...