Using cryo-EM, researchers elucidated the structure of key receptors integral to fast excitatory synaptic transmission in the rat cerebellum.

Algiax Pharmaceuticals, a company committed to developing innovative treatments for chronic neuropathic pain, has released positive topline data from its phase 2a clinical trial of AP-325. The trial ...

This research has elucidated the structure of GABAA receptors, and the nineteen subunits they carry. It can also show how some drugs interact with this receptor. The samples used in this study were ...

These receptors are targeted by many drugs for a variety of conditions, and by studying receptors directly from human brains, this research provides new insights into their exact structure ...

Structure Therapeutics is developing a series of both DACRAs and SARAs, as both approaches have demonstrated potential as obesity and chronic weight management treatment. Structure’s lead amylin-based ...

Germany, have developed a new method that makes it possible for the first time to image the three-dimensional shape of ...

The review also emphasizes the close relationship between the structure and function of these receptors: the subunit composition determines the pharmacological activity of the ligands. This ...

The review also emphasizes the close relationship between the structure and function of these receptors: the subunit composition determines the pharmacological activity of the ligands. This ...

Scientists have revealed the molecular structure of a type of receptor that's crucial to brain development and function. 'This study shows the dominant assemblies and states of the GABA receptor ...

Scientists have revealed the molecular structure of a type of receptor that’s crucial to brain development and function. “This study shows the dominant assemblies and states of the GABA ...

We use homology modelling, mutagenesis and electrophysiological techniques to examine the relationship between structure and function of GABAA receptors and other related Cys-loop receptors. We ...