The conversion of acetylcholine binding into ion conduction across the membrane is becoming more clearly understood in terms of the structure of the receptor and its transitions. A high-resolution ...

Signal transduction upon receptor activation depends on the binding ligand and the structure of the receptor. Upon the binding of different ligands, APJ may transduce a signal either through G protein ...

A membrane transport protein called SLC13A5 has previously been linked to a severe form of epileptic encephalopathy.

Using cryo-EM, researchers elucidated the structure of key receptors integral to fast excitatory synaptic transmission in the rat cerebellum.

γ-Aminobutyric acid type A receptors (GABAA receptors) are ligand-gated chloride channels that play a central role in signal transmission within the mammalian central nervous system. Compounds that ...

Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo [1,2-a]pyridine Structure Ivana Mejdrová ...