Structure of crucial receptor in brain development, ... Cryo-EM structures reveal native GABAA receptor assemblies and pharmacology. Nature, 2023; DOI: 10.1038/s41586-023-06556-w; ...

The scaffolding molecules form a 5-nm thick density sheet to support and regulate GABAA receptors on the membrane. Together, they form an absorbing semi-ordered structure called "mesophasic assembly".

Bird’s-eye view of this GABAA receptor shows its α1, β2, and γ2 subunits gathered around a central ion channel. [Courtesy of Zhu et al., 2018, Nature.] In GABA A receptors, five subunits ... Crystal ...

These receptors are crucial molecules that help control the movement of ions in and out of cells, a process that has many important impacts. As such, GABAA receptors have been the target of drugs ...

Paul S. Miller and A. Radu Aricescu, structural biologists at the University of Oxford, in England, have obtained the first crystal structure of a human GABA A receptor, at 3-Å resolution (Nature ...

Yet due to technical limitations and the delicate nature of studying human brain tissue, scientists have lacked a complete picture of how GABA A receptors, and their 19 subunits, come together to ...

When released, it binds to neurons at one of two receptors, GABAA and GABAB, and slows their firing rates. GABA is one place for researchers to start looking to understand neuropsychological ailments.

Scientists have revealed the molecular structure of a type of receptor that’s crucial to brain development and function. “This study shows the dominant assemblies and states of the GABA receptor.

Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer. Nature. 2019 Jan 2; PubMed. Masiulis S, Desai R, Uchański T, Serna Martin I, Laverty D, Karia D, Malinauskas T, Zivanov J, ...

HOUSTON – (Dec. 20, 2007) –When fruit flies lack a receptor for the inhibitory neurotransmitter gamma aminobutyric acid (GABA), their ability to learn or remember is enhanced, the first time ...