Genetically modified mice are made in a mixed or inbred background but for experimental reasons they are often backcrossed into other inbred backgrounds. The genetic background has a major impact on ...

With Guihong Tan, a research associate in the lab, she is working to identify all the genes across 200 isolates whose effects are modified by the genetic background.

Study reveals how genetic background influences trait inheritance laying the grounds for predicting personal risk of disease. Almost every family has a hard-drinking, bacon-loving, exercise-averse ...

CRISPR-Cas9, the new gene modification tool, which has been heralded as a means for inserting ourselves into evolution, ... given the right genetic background or conditions.

Two women have the same genetic mutation – an abnormal BRCA1 gene that puts them both at much higher-than-average risk for breast cancer – but only one woman develops the disease. Why?

Genetic modification is the process of altering the genetic makeup of an organism. This has been done indirectly for thousands of years by controlled, or selective, breeding of plants and animals.

Researchers at The Jackson Laboratory and Trudeau Institute have identified the first mouse strain that is susceptible to severe COVID-19 without the need for genetic modification. This ...

Turning to genetic modification could be a solution for a number of genetic diseases including sickle cell anemia, muscular dystrophy and cancer. This can be done through modifying human embryos ...