Forty years after the first effort to extract mummy DNA, researchers have finally generated a full genome sequence from an ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can ...

More information: Qixuan Wang et al, Spatial 3D genome organization reveals intratumor heterogeneity in primary glioblastoma samples, Science Advances (2025). DOI: 10.1126/sciadv.adn2830 ...

To overcome these limitations, the researchers integrated ATAC-seq, which detects open (active) chromatin regions, with Hi-C, which maps genome-wide chromatin interactions. The resulting technique ...

Chinese researchers have developed a technology that sheds light on how the three-dimensional (3D) organization of plant genomes influences gene expression—especially in photosynthesis.

Using their newly developed Hi-C technique, the scientists could chemically link nearby DNA regions and then sequence the resulting fragments to map their positions in three-dimensional space.

Hi-C—which cross-links, fragments, and then sequences pieces of DNA to see which regions regularly interact—confirmed that DNA did not tangle within the nucleus.

Figure 1. Biop-C method enables the study of high-resolution 3D genome organization and chromatin interactome in solid tumor samples. (A) Schematic overview of the Biop-C method. The frozen needle ...

Two new landmark studies show how a seeming tangle of DNA is actually organized into a structure that coordinates thousands of genes to form a sperm cell. The work, published March 3 as two papers in ...

Analyzing the DNA, RNA, and chromatin simultaneously from a single cell (Opens Over the past twenty years, techniques like Hi-C have been developed to determine chromatin structures. Hi-C links ...

With generative AI, chemists quickly calculate 3D genomic structures Date: January 31, 2025 Source: Massachusetts Institute of Technology Summary: Chemists have found a new way to determine 3D ...

MIT chemists have now come up with a new way to determine those 3D genome structures, using generative artificial intelligence. Their technique can predict thousands of structures in just minutes ...