When DNA breaks inside the cell, it can spell disaster, especially if the damage occurs in areas of the genome that are difficult to repair. Now, scientists Irene Chiolo and Chiara Merigliano at ...

Cells are constantly subjected to DNA damage from a range of internal and environmental sources. It is estimated that cells can experience as many as 100,000 DNA lesions per day. One of the most ...

Suspecting that autophagy might promote the use of HR over error-prone repair pathways, the research team investigated its effect on gene editing. When autophagy was triggered—either by nutrient ...

More information: Sina Shadfar et al, The Redox Activity of Protein Disulphide Isomerase Functions in Non‐Homologous End‐Joining Repair to Prevent DNA Damage, Aging Cell (2025).

Cells are constantly subjected to DNA damage from a range of internal and environmental sources. It is estimated that cells can experience as many as 100,000 DNA lesions per day. One of the most ...

Histone H1 deamidation regulates DNA double-strand break repair Repair of DNA double-strand breaks requires chromatin opening; however, the mechanisms involved were unclear.

The DNA damage response is a network of cellular pathways that sense, signal and repair DNA lesions. Surveillance proteins that monitor DNA integrity can activate cell cycle checkpoints and DNA ...