Figure 1. The insulin receptor substrate paradox. IGF-IR = Type 1 IGF receptor; IRS-1 = Insulin receptor substrate-1.

Importantly, the pro-oncogenic activities of IGF-1R are highly dependent on its proximal downstream effectors: insulin receptor substrate 1 (IRS1), and IRS2. 31, 32 IRS1 is upregulated in primary ...

THE IGF system comprises a phylo-genetically ancient family of peptides involved in growth, development, and metabolism, as well as in cellular processes such as proliferation, survival, cell ...

Viridian Therapeutics Inc. (NASDAQ:VRDN) is one of the best low priced pharma stocks to buy now. Earlier on May 20, Viridian ...

The Palsonify-treated subjects maintained control, with stable growth hormone levels, symptom scores, and pituitary tumour ...

Inhibition of Src and insulin/insulin-like growth factor-1 receptor (IR/IGF-1R) on tumors and bone turnover in prostate cancer (PCa) models in vivo compared with inhibition of either kinase alone.

Data show that PALSONIFY was well tolerated and IGF-1 levels remained stably controlled during long-term open label ...

"The results clearly showed that it is the insulin receptor -- not the IGF-1 receptor -- that is critical for the islet cell growth response to insulin resistance," said Dr. Kulkarni.

In a paper published in Diabetes, they show that, in Type 1 diabetes patients, verapamil prevented the decline of the hormone insulin-like growth factor 1, or IGF-1, as compared to controls who did ...

The precise genes involved in the control of ageing have been unclear, but several studies from invertebrates studies suggest that some of these life span genes encode components of the insulin or ...

The original methods for targeting the IGF-I receptor in experimental animals were antisense strategies and dominant-negative mutants of the receptor. They are obsolete. Several antibodies to the ...