Amyloid precursor protein (APP)-derived amyloid-β (Aβ) peptides form pathological aggregates in Alzheimer’s disease (AD).

This study reports the important development and characterization of next-generation analogs of the molecule AA263, which was previously identified for its ability to promote adaptive ER proteostasis ...

Scientists have discovered that a protein once thought to be just a cellular "courier" actually helps plants survive drought. This motor protein, myosin XI, plays a critical role in helping leaves ...

In this new study, scientists have introduced an innovative strategy to trap these enzymes within nanoscale protein compartments produced naturally by bacteria, simplifying their use and extending ...

These findings highlight the dual roles of antioxidants in cancer. Their impact depends on cancer type, stage, and genetic ...

Protein quality control articles from across Nature Portfolio Protein quality control is the mechanism by which a cell monitors proteins to ensure that they are appropriately folded. Protein ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

Whole-mount 3D imaging at the cellular scale is a powerful tool for exploring complex processes during morphogenesis. In organoids, it allows examining tissue architecture, cell types, and morphology ...