The following is a summary of “Novel protein C variant p.C101F results in early intracellular degradation that drives type I ...

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Prof. Ciechanover discussed the history of ubiquitin and the crucial role of intracellular protein degradation in quality control, cellular processes, and differentiation. He also highlighted the ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

Unlock the secret to building muscle without lifting heavy weights using science-backed methods that maximize growth with lighter workouts.

After validating its efficacy, they designed and synthesized another clozapine PROTAC targeting the estrogen receptor alpha (ERα), which was shown to induce degradation of the ERα protein in MCF-7 ...

In his talk, Prof. Ciechanover discussed the history of ubiquitin and the crucial role of intracellular protein degradation in quality control, cellular processes, and differentiation. He also ...

Successful research in targeted protein degradation depends not only on measurements at high sensitivity, speed and precision ...

Proteins in cells are highly flexible and often exist in multiple conformations, each with unique abilities to bind ligands.