Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...

The Semaglutide peptide has emerged as a compelling subject in biochemical and physiological research due to its potential ...

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness. These ...

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells.

Intracellular protein trafficking and secretion of proteins into the extracellular environment are sequential and tightly regulated processes in eukaryotic cells.

After a heart attack, this process of degradation has to be stopped so that tissues can health better. The protein-like polymer, or PLP, platform is made from a polymer that mimics Nrf2. Once injected ...

The launch of its N-terminal Edman Degradation Service underscores this commitment, providing researchers with a powerful tool to address complex protein sequencing challenges. About Creative ...

The study, published in Molecular Cell, revealed which Ubiquitin code can or cannot induce intracellular protein degradation. Proteins are the building blocks of life, maintaining cellular ...

To unravel this ubiquitin code and understand protein degradation better, Leo Kiss and Brenda Schulman in collaboration with Leo James, head of the research group “Host-Pathogen Biology”, at the MRC ...

“Protein degradation is based on intracellular processes, and it builds on the cell's natural system for recycling unneeded or defective proteins. This disposal process, which is called the ubiquitin ...

Exposure to exogenous and endogenous stress is associated with the intracellular accumulation of aberrant unfolded and misfolded proteins. In eukaryotic cells, protein homeostasis within ...