Amyloid precursor protein (APP)-derived amyloid-β (Aβ) peptides form pathological aggregates in Alzheimer’s disease (AD).

Scientists have discovered that a protein once thought to be just a cellular "courier" actually helps plants survive drought. This motor protein, myosin XI, plays a critical role in helping leaves ...

In this new study, scientists have introduced an innovative strategy to trap these enzymes within nanoscale protein compartments produced naturally by bacteria, simplifying their use and extending ...

Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...

The Semaglutide peptide has emerged as a compelling subject in biochemical and physiological research due to its potential ...

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

The lysosome-targeting chimera (LYTAC) approach, especially aptamer-based LYTAC, has shown promise for the targeted degradation of secreted and membrane proteins. However, the conventional monovalent ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of RNA-based drugs can significantly enhance their effectiveness. These ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...

Thus, deciphering the initial steps in the degradation of ubiquitinated PM proteins, which is the major focus of this review, will greatly contribute to the larger question of how plants mange to fine ...