Every organism on Earth is a well-oiled machine in its own environment. It makes sense then that every piece of every process ...

The following is a summary of “Novel protein C variant p.C101F results in early intracellular degradation that drives type I ...

The amount of protein an individual needs depends on their age and sex. However, most adults on a 2,000-calorie diet require 50 grams (g) of protein daily. Protein is a part of every cell in the ...

The intestinal epithelium is a highly dynamic barrier that regulates digestion, absorption, immune responses, and communication between the gut microbiota and the nervous system. To maintain ...

Unlocking the potential of protein degradation in cancer research Donate Research and discoveries Study and careers Industry partnerships About us Support us Research and discoveries Find a researcher ...

It is observed that GSD can surpass the off-state degradation (OSD) stress mode. By separating different types of traps, we clarified the physical mechanism of GSD. Based on the understanding, a ...

Prof. Ciechanover discussed the history of ubiquitin and the crucial role of intracellular protein degradation in quality control, cellular processes, and differentiation. He also highlighted the ...

In his talk, Prof. Ciechanover discussed the history of ubiquitin and the crucial role of intracellular protein degradation in quality control, cellular processes, and differentiation. He also ...

After validating its efficacy, they designed and synthesized another clozapine PROTAC targeting the estrogen receptor alpha (ERα), which was shown to induce degradation of the ERα protein in MCF-7 ...

Since the degradation of most proteins is mediated by E3 ubiquitin ligases, the team further investigated and identified DTX2 as the E3 ubiquitin ligase involved in VES-mediated FTO degradation.