Some two dozen biotech developers of PROTACs, molecular glues and other types of protein-degrading drugs have sprung up over ...

Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming different chains. Researchers at the Max Planck Institute of ...

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

03/24/2025 19:21 Cracking the Code of Protein Degradation Dr. Christiane Menzfeld Öffentlichkeitsarbeit Max-Planck-Institut für Biochemie. Ubiquitin marks proteins for degradation, whereby ...

EpiTACs are an example of an extracellular protein degradation therapeutic. These are tissue-specific bispecific antibodies in which one arm binds a target and the other arm binds a degrader receptor.

Targeted protein degradation (TPD) is a promising therapeutic strategy that repurposes machinery within the cell to target faulty proteins for destruction. One such technology, lysosome-targeting ...

Itakura says, "In the future, elucidating the molecular mechanism of protein degradation by extracellular chaperones may prove useful in treating related diseases, like Alzheimer's disease.

After binding to membrane proteins, SignalTACs dissociate from the membrane protein in the acidic endosomal compartment and enter lysosomes for degradation. The Cation-Independent Mannose-6-Phosphate ...

To unravel this ubiquitin code and understand protein degradation better, Leo Kiss and Brenda Schulman in collaboration with Leo James, head of the research group “Host-Pathogen Biology”, at the MRC ...

Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming different chains. Researchers at the Max Planck Institute of ...