Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

Intracellular constituents such as proteins and organelles are turned over by unremitting synthesis and degradation. This dynamic turnover is critical for homeostasis, development, and environmental ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

The following is a summary of “Novel protein C variant p.C101F results in early intracellular degradation that drives type I ...

Unlocking the potential of protein degradation in cancer research Donate Research and discoveries Study and careers Industry partnerships About us Support us Research and discoveries Find a researcher ...

A research team at POSTECH (Pohang University of Science and Technology) has successfully developed a super-photostable ...

A new role of calcium in the development of muscles has been reported by two RIKEN biologists. Stress is generally damaging and destructive, but it can sometimes spur productivity and creation. This ...

and is trying to clarify various questions related to intracellular degradation. A common mechanism of eukaryotes, from yeast to humans. It prevents the accumulation of abnormal proteins. And it also ...

Prof. Ciechanover discussed the history of ubiquitin and the crucial role of intracellular protein degradation in quality control, cellular processes, and differentiation. He also highlighted the ...

We are developing technologies using intracellular antibodies with warheads (such as E3 ligase for protein degradation or pro-caspases for induced cell death) together with methods to allow systemic ...