This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

While autophagy is relevant to many biological processes and often serves as a gatekeeper of homeostasis, when something goes wrong it can either lead to disease or be activated to fight against it.

Henan Key Laboratory of Environmental and Animal Product Safety, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471000, Henan,China ...

The roles of key proteins such as the microtubule-associated protein 1 light chain 3 (LC3), beclin 1, and p62 in autophagy initiation and substrate recognition were also explored. Further ...

Recycling takes place in our cells at all times: in a process called autophagy, cell components that are no longer needed are enclosed by membranes and broken down into their basic building blocks.

How our cells dispose of waste and ways to control it Date: January 7, 2025 Source: University of Freiburg Summary: Cells degrade components that are no longer needed through autophagy. New ...

After formation of the autolysosome, the lysosomal hydrolases degrade the intra-autophagosomal contents, including LC3-II. Figure 4. Effects of TSH on thyrocyte autophagy. Activation of TSHR by TSH ...

The defect in autophagy by the depletion of axonal mitochondria is one of the main claims in the paper. The authors should work more on describing their results of LC3-II/LC3-I ratio, as there are ...

The purpose of this work is thus to learn if P2X7 might participate to ALS pathogenesis by directly modulating autophagy, and particularly the expression of the autophagosome component LC3-II and of ...