in post-stroke neuroinflammation. Immunofluorescence staining of mouse brains revealed that NLRC5 was mainly expressed in microglia.

Methods: We used superparamagnetic iron oxide to induce COHT in mice. Apoptosis of retinal ganglion cells (RGCs) and activation of microglia were evaluated using western blotting (WB) and ...

We tested valproate, topiramate and lamotrigine in the MPTP mouse model ... significantly limited neuronal death in the SNpc. Our active caspase 3 staining study shows that this protection ...

Background: Microglia-mediated inflammatory response directly affects ischemic stroke outcome. Autophagy is crucial in inflammatory response after cerebral ischemia. NLRC5 can be a positive or ...

Linh Le, Ph.D., currently a Research Scientist, found the expected response from microglia to PLX3397 in male mice—it blocked the receptor that signals microglial survival and depleted the ...

This study presents a valuable finding on the function of the gene Cst7 in sex-divergent pathological changes in microglia in a mouse model of amyloid-driven Alzheimer's disease. The evidence ...

For immunofluorescence staining, brain sections were blocked in PBS-T ... chemokines in the culture supernatants of primary astrocytes and microglia and homogenates of mouse striatum according to the ...

Here we show that in mouse development, as well as in adult mouse and zebrafish, CVO ECs rendered Wnt-reporter negative, suggesting low level pathway activity. Characterization of the subfornical ...