The normal functioning of p53 is a potent barrier to cancer. Tumour-associated mutations in TP53 are a hallmark of most human cancers and cause dramatic defects in p53 function.

In this study, we used the high-throughput Sequenom MassArray approach to investigate single-nucleotide mutations and polymorphisms in 33 genes in a cohort of borderline ovarian tumors to ...

Duchenne and Becker muscular dystrophies (D/BMD) are caused by mutations in the dystrophin gene. Two-thirds of patients have large intragenic deletions or duplications and the remaining one-third ...

Human Genetics: Concepts and Application Because of natural selection, different alleles are more likely to confer a survival advantage in different environments. Cycles of infectious disease ...

The Mutation Sensation: Cleavase Fragment Length Polymorphism from Third Wave Technologies p53 GENE MUTTION: Exons 5 and 6 of the p53 gene of five individuals were amplified and examined by Cleavase® ...

There is a remarkable snail with breathtakingly beautiful shells that can only be found in Cuba. It is not native to any ...

A new study from the University of Michigan Rogel Health Cancer Center, published in Science, sheds light on how two distinct classes of mutations in the FOXA1 gene—commonly altered in prostate cancer ...

Researchers identified an unusual genetic mutation in orange domestic cats that has not been found in any other animal, according to a new study.

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

Organ transplantation has significantly revolutionized the treatment of patients with organ failure. However, the recipient's immune system recognizes transplanted organs as foreign and elicits a ...

More than 10% of older adults develop somatic (non-inherited) mutations in blood stem cells that can trigger explosive, clonal expansions of abnormal cells, increasing the risk for blood cancer ...

e21065Background: Somatic mutations in the promoter of the telomerase reverse transcriptase gene (TERT) appear to confer a worse prognosis in several cancers, an effect which may be modulated by ...