This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

Parkinson’s disease is a brain disorder that affects movement, making everyday tasks difficult for nearly one million people ...

Autophagic flux was examined by the buildup of p62 or ubiquitinated organelle protein. Endolysosomal structures were examined by electron microscopy. Cell-specific autophagy was evaluated by ...

cGAS can also act as a selective autophagy receptor for micronuclei causing their ultimate degradation and thereby prohibiting them from releasing DNA into the cytosol. Finally, K48-linked ...

Introduction: Renal podocyte injury, apoptosis and autophagy are involved in the occurrence and development ... Atg7 and Atg 5, and downregulated p62/SQSTM1), accompanied by inhibited renal apoptosis ...

This Patent Highlight integrates bifunctional degraders, leveraging autophagy via p62, and substituted oxazolone compounds targeting IKZF1–4 transcription factors. These compounds demonstrate ...

The DF-O and MPs samples suppressed autophagy by decreasing expression levels of microtubule ... while increasing the level of p62. Meanwhile, DF-O and MPs samples induced apoptosis through increasing ...