Several studies have reported potentially anti-inflammatory effects of PPAR-γ ligands in monocytes and macrophages. Treatment of monocytes and macrophages with high concentrations of PPAR-γ ...
Though ERs are primary targets of EDCs, other members of the NR family, including AR, ERRγ, PPARs, TRs, RXRs, and PXR have been shown to correspond to secondary targets of EDCs. The weak structural ...
Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an important role in SSc-related fibrosis and their agonists may become effective therapeutic targets. Objective To ...
dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...
Modulation of Protein–Protein Interactions with Molecular Glues in a Synthetic Condensate Platform
We used the autofluorescent PPARγ ligand chiglitazar, omitted from the original ligand panel due to its autofluorescence, to probe the partitioning coefficients of such ligands. Chiglitazar contains a ...
Laboratory of Biophysical Chemistry of Macromolecules, Institute of Chemical Sciences and Engineering (ISIC), School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland; ...
A subset of these lipid mediators (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these receptors occurred specifically during hyperactive IFN ...
Figure 4 PPARs in macrophage function and polarization ... Interestingly, LTB4 and other fatty acid derived molecules are ligands for PPARα, thus this feedback loop promotes their own catabolism and ...
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