Unlike prostacyclin analogues, it has high specificity for the ... This switch to glycolysis for ATP synthesis, called the Warburg effect, was originally described in cancer cells. Although dependence ...

Figure 1 Typical chronology of cellular events during tumour progression. Figure 2 Formation of different reactive products from nitric oxide. Pleiotropic biological effects of NO may depend upon this ...

Patients were randomized to ticlopidine (500 mg), an antiplatelet agent that does not interact with prostaglandin synthesis, or aspirin (325 mg). Hemodynamic evaluation performed after 7 days of ...

Future Cardiol. 2013;9(3):335-349. Research into prostacyclin analogs for the treatment of WHO Group 2 PH has been limited, likely due to the early termination of the FIRST trial. [55] This study ...

A recent breakthrough by researchers from Shinshu University, Japan, is changing this landscape. The team has successfully achieved the first total synthesis of inaoside A, a natural compound found in ...

4 University of Giessen and Marburg Lung Center (UGMLC), member of the German Center of Lung Research (DZL), Giessen, Germany Until recently, three classes of medical therapy were available for the ...

Prostaglandin E2 (PGE2) is an important prostanoid expressing throughout the kidney and cardiovascular system. Despite the diverse effects on fluid metabolism and blood pressure, PGE2 is implicated in ...

Maintenance of cerebral blood vessel integrity and regulation of cerebral blood flow ensure proper brain function. The adult human brain represents only a small portion of the body mass, yet about a ...

Introduction Sepsis is a leading global cause of morbidity and mortality, and is more common at the extremes of age. Moreover, the cost of in-hospital care for elderly patients with sepsis is ...