Approximately 40–50 percent of all drugs targets are G protein-coupled receptors (GPCRs). Three-dimensional structure of GPCRs is important to probe their biophysical and biochemical functions and ...

KEYWORDS: Protein Folding, Gibbs Free Energy, Quantum Statistic, Single Molecule JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.6 No.1, January 29, 2015 ABSTRACT: Anfinsen’s thermodynamic ...

Josiah Willard Gibbs, an American mathematician, first described Gibbs free energy in the 1870s. According to Gibbs, free energy is the total energy of a system that is available to perform useful ...

Study findings The Gibbs energy of binding of the SARS-CoV-2 Omicron subvariant BA.2.75 was -49.41 kJ/mol, while that of BA.4 and BA.5 were -45.81 kJ/mol and -44.95 kJ/mol, respectively.

Thanks to AI, we just got stunningly powerful tools to decode life. In two back -to- back papers last week, scientists at DeepMind and the University of Washington described deep learning-based ...

Solvation free energy is a fundamental property that influences various chemical and biological processes, such as reaction rates, protein folding, drug binding, and bioavailability of drugs. In this ...

It's commonly accepted that protein folding/misfolding are alternative reactions of unfolded proteins but the principles governing this remain unknown. Here, researchers describe a general concept ...

"This computational work represents a stunning advance on the protein-folding problem, a 50-year-old grand challenge in biology," Venki Ramakrishnan, president of the Royal Society in the United ...