SARS-CoV-2 secondary structure shapes mutation frequencies, constraining viral evolution models predicting fitness can benefit from integrating secondary structure data.

The rRNA molecules fold into complex secondary and tertiary structures, forming domains and motifs that ... This discovery led to the concept of the ribosome as a ribozyme, an RNA molecule with ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are ...

Consideration of the energetics of ion binding at specific sites suggests that both monovalent and divalent cations can be important stabilizers of RNA tertiary structures.

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are utilized to cure diseases. RNA has recently gained attention as a promising ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...

When performing RNA interference (RNAi) experiments, the first critical challenge is the design of efficient small interfering RNAs (siRNAs). MWG Biotech has created an online design tool allowing ...

The intrinsically disordered proteins (IDPs) do not attain a stable secondary or tertiary structure and rapidly change their conformation, making structure prediction particularly challenging.

Reference: Kagaya Y, Zhang Z, Ibtehaz N, et al. NuFold: end-to-end approach for RNA tertiary structure prediction with flexible nucleobase center representation. Nat Commun. 2025;16(1):881. doi: ...