CRISPR SNP-Chip can detect and quantify single point mutation directly from unamplified whole genomic DNA samples without laborious sample preparation or optical instruments.

Chemistry researchers have found the key to a SNP (single nucleotide polymorphism) - a natural mutation in humans - which offers protection against cardiovascular disease, and could enable drug ...

Melissa Gymrek and colleagues estimate mutation parameters for each short tandem repeat (STR) in the human genome. They find that local sequence features impact these estimates and they create a ...

Patients were assessed for the presence of the intron 6 SNP as well as a number of other mutations related to liver enzymes. Among those taking the three relevant statins, 22 were carriers of the ...

SNP selection. The previous autosomal recessive RP-LCA chip analyzed four SNPs for 22 arRP-arLCA genes. 3 Now, the chip has been enlarged with two SNPs per gene to increase the informativity. To ...

In fact, SNP-Chip stands to enable easy and point-of-care electronic screening for a wide range of genetically driven health issues, since SNPs make up 50 percent of mutations known to cause ...

A tiny gene mutation in human liver cells could one day influence how high or low a dose patients need of about half of the clinically used drugs on the market, new research suggests. Scientists ...

New mathematical model explains variability in mutation rates across the human genome Date: February 19, 2016 Source: Perelman School of Medicine at the University of Pennsylvania ...

Testing identified mutations by using gRNAs that target specific sequences of DNA where the mutations are located. "SNP-Chip's digital, direct, rapid, and accurate SNP analysis will revolutionize the ...

A team led by the University of California San Diego has developed a chip that can detect a type of genetic mutation known as a single nucleotide polymorphism and send the results in real time to ...

It turns out that the type, how frequent, and where new mutations occur in the human genome depends on which DNA building blocks are nearby, found researchers from the Perelman School of Medicine ...

A tiny gene mutation in human liver cells could one day influence how high or low a dose patients need of about half of the clinically used drugs on the market, new research suggests.