Higher daily dexamethasone doses can be given to patients who do not respond to the usual initial dose. Response is usually measured in terms of improvement in neurological deficits within 48 hours.

Dexamethasone Tapering Corticosteroid therapy must be tapered because of its interactions with the hypothalamic-pituitary-adrenocortical (HPA) axis. The hypothalamus secretes corticotropin ...