Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...
This valuable work presents how PRDM16 plays a critical role during colloid plexus development, through regulating BMP signaling. Solid evidence supports the context-dependent gene regulatory ...
A protein called CcUNE10, which is part of the bHLH transcription factor family, played an important role by binding to and activating certain genes involved in chlorophyll degradation.
Transcription cofactors are often large protein assemblies that help to activate or repress transcription. The transcriptional outcome depends on the transcription factors binding to regulatory ...
Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss hormonal therapy updates and different ways to target and ...
Considering Abundance, Affinity, and Binding Site Availability in the NF-κB Target Selection Puzzle
Computing fraction of binding sites occupied by transcription factor. Computational models provide a powerful ... and of processing and degradation of inhibitory domains (ankyrin-rich domains of p105 ...
Conclusions These findings support the key role of TLR4 in Kupffer cells in mediating the progression of simple steatosis to NASH, by inducing ROS-dependent activation ... X-box binding protein-1 (XBP ...
New inhibitor of the noncanonical NF-κB pathway specifically binding to RelB shows antitumor effect
The transcription factor nuclear factor-κB (NF-κB) family has a central regulatory role in the expression of many genes related to immune responses, inflammation, cell survival and cancer. Previous ...
Previous research revealed that nuclear factor of activated T cells 1 (NFAT1) is a novel regulator of the mouse double minute 2 homolog (MDM2) oncogene, which acts by directly binding to the MDM2 P2 ...
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