Torsional stress in chromatin plays a fundamental role in cellular functions, influencing key processes such as transcription, replication, and chromatin organization. Transcription and other ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

A protein called CcUNE10, which is part of the bHLH transcription factor family, played an important role by binding to and activating certain genes involved in chlorophyll degradation.

Conclusions These findings support the key role of TLR4 in Kupffer cells in mediating the progression of simple steatosis to NASH, by inducing ROS-dependent activation ... X-box binding protein-1 (XBP ...

However, domain knowledge from an expert is required. In this study, we propose an exploratory and interpretable approach to estimating latent health risk factors without relying on domain knowledge, ...

Official implementation of DTIAM, a unified framework for predicting drug-target interactions, binding affinities and activation/inhibition mechanisms, by Zhangli Lu. Please contact me if you are ...

the authors find the changes in binding specificity occur mainly through changes outside of the DNA binding domains, showing that novelties in transcription factor binding can occur through multiple ...

Promoter auto-activation was detected on SD medium lacking Ura in the presence of aureobasidin A (AbA) according to the system manual. Further, the coding sequence of screened transcription factors ...

Here we describe existing methodology to perform these two tasks for motifs characterizing transcription factor ... binding of TF PU.1 to DNA. (A) Direct binding of PU.1 to DNA to the consensus motif ...