The process of transcription elongation by RNA polymerase II (Pol II), in which Pol II travels along DNA and synthesizes RNA from DNA, is essential for proper gene expression in all eukaryotic cells.

Researchers at Fred Hutch and MD Anderson discovered RNA Polymerase II on histone genes as a biomarker for cancer ...

It both stabilizes a critical protein called RNA Polymerase II—the molecular engine of gene transcription—and reshapes the structure of chromatin, the tightly packed form of DNA, to activate ...

Using a new technology and computational method, researchers from Fred Hutch Cancer Center and The University of Texas MD Anderson Cancer Center have uncovered a biomarker capable of accurately ...

Using a new technology and computational method, researchers have uncovered a biomarker capable of accurately predicting outcomes in meningioma brain tumors and breast cancers.

Here, the authors show that under acute heat shock, it selectively arrests cellular transcription and translation, independent of the signal peptide. Wang et al. demonstrate that the vascular ...

The new technology – Cleavage Under Targeted Accessible Chromatin (CUTAC) – focuses on small, fragmented DNA non-coding ...