The Cleveland Guardians (40-43) and Chicago Cubs (50-35) play the second game of a 3-game series Wednesday at Wrigley Field. The contest is slated for an 8:05 p.m. ET (ESPN) start time. Let's analyze BetMGM Sportsbook's MLB odds around the Guardians vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Matt Shaw hit a walk-off sac fly in the 10th inning to help the Cubs beat the Cleveland Guardians on July 3 to complete a 3-game sweep in Chicago.

Chicago Cubs President Jed Hoyer said left-hander Matthew Boyd has “exceeded expectations” with his stellar first half of the season.