Cardiovascular disease (CVD) remains a major health burden despite significant therapeutic advances accomplished over the last decades. It is widely and increasingly recognized that systemic ...

Due to improvements in recognition and management of their multisystem disease, the long‐term survival of infants, children, and adolescents with trisomy 21 and congenital heart disease now matches ...

Background— The management of aortic intramural hematoma (IMH) involving the ascending aorta (type A) has not been well-established. The purpose of this study was to clarify the long-term clinical ou ...

HIV type 1 (HIV-1) is the causative agent of AIDS. Since the start of the epidemic, HIV/AIDS has been responsible for ≈40 million deaths. Additionally, an estimated 39 million people are currently ...

In this issue of Circulation, Mukamal and colleagues report that frequent moderate consumption of alcohol is inversely associated with incident myocardial infarctions for both men and women. 1 This ...

Abstract Europe and North America are the 2 largest recipients of international migrants from low‐resource regions in the world. Here, large differences in cardiovascular disease (CVD) morbidity and ...

The thorough prospective, randomized, double-blind trial of Schmieder et al 1 in the current issue of Circulation convincingly documents that aliskiren treatment provided significantly greater blood ...

Background—Youthful age has been considered the time of greatest risk for patients with hypertrophic cardiomyopathy (HCM), largely because of the possibility of sudden death. The last 2 decades have ...

Conclusions Evidence reveals a negative association between arterial stiffness, measured using pulse‐wave velocity, and cognition, specifically executive function, memory, and global cognition. This ...

Current American Heart Association (AHA) diet and lifestyle recommendations for both children and adults emphasize these goals: aim for a healthy body weight and recommended levels of blood lipids and ...

Background—By its inhibitory effect on platelet-derived growth factor signaling, imatinib could be efficacious in treating patients with pulmonary arterial hypertension (PAH). Methods and Results—Ima ...

Background—Beyond their role as innate immune effectors, natural killer (NK) cells are emerging as important regulators of angiogenesis and vascular remodeling. Pulmonary arterial hypertension (PAH) ...