A pillar of the WHO End TB Strategy is targeted latent tuberculosis infection (LTBI) testing to identify persons who would benefit from TB preventive treatment (TPT).1 The WHO recommends the ...

Background The aetiology of lung cancer among individuals who never smoked remains elusive, despite 15% of lung cancer cases in men and 53% in women worldwide being unrelated to smoking. Epigenetic ...

Introduction Directly Observed Therapy (DOT), and VOT are methods to ensure medication adherence and improve outcomes in patients with medically and socially complex TB. 1 2 We developed an in-house ...

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Background Oscillatory positive expiratory pressure (OPEP) devices are intended to facilitate sputum clearance and reduce cough, but there is limited evidence for their effectiveness in COPD, or to ...

Background We previously reported that microvesicles (MVs) released by human mesenchymal stem cells (MSC) were as effective as the cells themselves in both Escherichia coli lipopolysaccharide and live ...

Introduction Parkin (Park2), an E3 ubiquitin ligase, is critical to maintain mitochondrial function by regulating mitochondrial biogenesis and degradation (mitophagy), but recent evidence suggests the ...

Introduction This study aimed to construct artificial intelligence models based on thoracic CT images to perform segmentation and classification of benign pleural effusion (BPE) and malignant pleural ...

Introduction Identifying acute hypercapnic respiratory failure is crucial in the initial management of acute exacerbations of COPD. Guidelines recommend obtaining arterial blood samples but these are ...

Lung cancer outcomes have improved only marginally over the last 40 years and remain dismally poor in comparison to most other cancers: only 17.7% of women and 12.9% of men in the UK survive after ...

The National Aspergillosis Centre, University Hospital of South Manchester, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK Correspondence to Dr Chris Kosmidis, ...

5 Greater Manchester, Lancashire, South Cumbria Strategic Clinical Network, Manchester, UK We report results from the second annual screening round (T1) of Manchester’s ‘Lung Health Check’ pilot of ...