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Among the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins by ...

In “Let-7a-regulated translational readthrough of mammalian AGO1 generates a microRNA pathway inhibitor” by Singh et al, 2019, and “Transcript-specific induction of stop codon readthrough using a ...

Results In this study, we show how hyperoxia at birth increases the number of alveolar type 1 (AT1) epithelial cells expressing the proliferation protein Ki-67 in adult mice. Although these cells were ...

Wound healing is a multifaceted and dynamic sequence of tissue repair and regeneration processes involving interrelated stages: inflammation, regeneration, and remodeling. Throughout these processes, ...

Exhaustion of CD8 + T-cells leads to their reduced immune functionality and is controlled by numerous transcription factors. Here we show that the transcription factor IRF-5 helps to limit functional ...

Oral leukoplakia (OLK) is a common potentially malignant oral disorder with high risk of malignant transformation. While photodynamic therapy (PDT) offers a minimally invasive treatment for OLK, some ...

Abstract Chromatin modifications play an important role in transcription, DNA replication and repair. Nonetheless, whether histone modifications regulate replication stress responses remains obscure.

Chromatin modifications play an important role in transcription, DNA replication and repair. Nonetheless, whether histone modifications regulate replication stress responses remains obscure. Here, we ...

In this study, we demonstrated that the druggable NCoR1/RARα axis is a promising target for selective inhibition of CMA in NSCLC. Furthermore, we developed CIM7, a first-in-class small molecule ...

Abstract The mitochondrial F 1 F 0 -ATP synthase is crucial for maintaining the ATP/ADP balance which is critical for cell metabolism, ion homeostasis and cell proliferation. This enzyme, conserved ...

Introduction A longstanding vision for synthetic biology is the development of bacterial whole-cell biosensors and ‘sense-and-respond’ live biotherapeutic products. These systems promise to ...