The steroidogenic enzyme 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) correlates with tumor aggressiveness, and its inhibitors, biochanin-A (BCA) and the related analogs, have shown antitumor ...

Recent reports suggest that the US administration plans to eliminate the Environmental Protection Agency’s (EPA’s) Office of Research and Development (ORD) (1, 2). Most staff would be cut, with ...

Vibrio cholerae, known for its pathogenicity in humans, is most commonly a marine microbe that forms biofilms on chitin particles, which it can consume as a source of carbon and nitrogen. Upon ...

Maintenance of pH within membranous organelles is crucial for cellular processes such as posttranslational modifications, ligand–receptor interactions, and proteostasis. The precise mechanisms that ...

Bispecific T cell engagers (TcEs) are immunotherapeutic drugs that trigger the destruction of cancer cells by linking T cells to cancer cells through specific surface molecules (antigens). We designed ...

The synthesis of new polyhydrides with high superconducting Tc is challenging owing to the high pressures and temperatures required. In this study, we used machine-learning potential molecular ...

Natural ice plays salient roles in making the Earth habitable and sustainable. Previously overlooked, its role in chemical processes is now of emerging interest, particularly due to the freeze ...

Greening immediately after etiolated-seedling’s emergence from the soil is critical for plants to initiate their autotrophic life cycle through photosynthesis. The greening process relies on a complex ...

We investigate mechanisms for the observed nonlinear growth in the number of polymer vesicles generated during a photo-Reversible Addition-Fragmentation Chain Transfer-based polymerization-induced ...

The tight link between brain and skull formation is a fundamental aspect of vertebrate evolution and embryogenesis. Their developmental synchronization is essential for structural and functional ...

Recent experiments have challenged the belief that glial cells, which compose at least half of brain cells, are just passive support structures. Despite this, a clear understanding of how neurons and ...

Potassium (K +) channels are essential membrane proteins that facilitate the selective conduction of K + ions while excluding Na + ions. Incorporation of electronic polarization effects through the ...