Jun 28, 2021 · In vivo histology using MRI (hMRI) aims to provide quantitative whole-brain measures of brain microstructure in health and disease. qMRI and hMRI promise much needed sensitive biomarkers...

Apr 27, 2022 · We present the first three-dimensional (3D) concordance maps of cyto- and fiber architecture of the human brain, combining histology, immunohistochemistry, and 7-T quantitative magnetic resonance imaging (MRI), in two individual specimens.

Aug 25, 2021 · The BigBrainWarp toolbox facilitates integration of 3D human brain histology with neuroimaging, helping neuroscientists to utilise cytoarchitectural information in conjunction with in vivo imaging.

Aug 14, 2020 · Here, we present an open-source computational pipeline to produce 3D consistent histology reconstructions of the human brain. The pipeline relies on a volumetric MRI scan that serves as...

Sep 28, 2017 · The following article is the first of a three-part series on imaging large whole mount brain sections for neuroscience research. The series covers sectioning/staining, scanning, and data...

Mar 14, 2018 · Modern clearing techniques for the three-dimensional (3D) visualisation of neural tissue microstructure have been very effective when used on rodent brain but very few studies have utilised...

Jun 18, 2018 · In this work we now demonstrate noninvasive imaging of paraffin-embedded human brain tissue by phase contrast based on electron density variations without any additional staining and at an image quality which enables reliable and automated rendering of up to 1.8 ⋅ 1 0 6 neurons in the reconstruction volume.

Aug 25, 2021 · Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, 'BigBrainWarp', that combines these developments.

Nov 23, 2023 · We used the Brainbox to acquire post-mortem ex vivo MRI of eight human brains, fresh and formalin-fixed, and correlated focal imaging features to histopathology using the built-in 3D coordinate system. With its built-in 3D coordinate system, the Brainbox allowed correlation of MRI features to corresponding tissue substrates.

Feb 6, 2024 · Here we present NextBrain, a next-generation probabilistic atlas of human brain anatomy built from serial 3D histology and corresponding highly granular delineations of five whole brain hemispheres.