Dec 24, 2024 · CYP2E1 (Cytochrome P450 Family 2 Subfamily E Member 1) is a Protein Coding gene. Diseases associated with CYP2E1 include Alcoholic Liver Cirrhosis and Alcohol Use …

Besides the detoxifying role of CYP2E1 for compounds such as electrophilic agents, reactive oxygen species, free radical products, and the bioactivation of xenobiotics, CYP2E1 is also …

CYP2E1 has the highest catalytic activity among the members of cytochrome P450 enzymes in metabolizing alcohol (ethanol). The role of CYP2E1 becomes particularly important when …

Cytochrome P450 2E1 (CYP2E1) plays a vital role in drug-induced hepatotoxicity and cancers (e.g. lung and bladder cancer), since it is responsible for metabolizing a number of …

The cDNA of human CYP2E1 can be successfully cloned, and a cell line, HepG2-CYP2E1 can efficiently express mRNA and has CYP2E1 activity. This study shown that the genotypes of …

May 1, 2020 · That role is shared with two other enzymes that oxidize ethanol, alcohol dehydrogenase and catalase. P450 2E1 is also involved in the bioactivation of a number of …

Cytochrome P450 2E1 (CYP2E1) is pivotal in hepatotoxicity induced by alcohol abuse and different xenobiotics. In this setting, CYP2E1 generates reactive metabolites inducing oxidative …

CYP2E1 is located within the placental trophoblast, and has been detected in this tissue during all three trimesters (Hakkola et al. 1996). CYP2E1 is most notably involved in the bioactivation of …

Jan 13, 2025 · CYP2E1 plays a major role in ethanol-induced fatty liver and oxidant stress. Data show that SZME3 induced an up-regulation of both Cyp1a1 and Cyp2e1 genes in both …

Feb 11, 2024 · Clinical resource with information about CYP2E1, Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women., …