Clindamycin exerts its bacteriostatic effect via inhibition of microbial protein synthesis. Clindamycin has a relatively short T max and half-life necessitating administration every six …

May 16, 2022 · Clindamycin is an older antibiotic that is used to treat bacterial infections including pneumonia, strep throat, osteomyelitis, and endocarditis. It was first synthesized in 1966 by …

Clindamycin is a semisynthetic derivative of lincomycin, a natural antibiotic produced by the actinobacterium Streptomyces lincolnensis. It is obtained by 7( S )- chloro - substitution of the …

Clindamycin prevents peptide bond formation, inhibiting protein synthesis by reversibly binding to 50S ribosomal subunits. Depending on the organism, infection site, and drug concentration, …

The phosphate ester of clindamycin, clindamycin phosphate, is rapidly hydrolyzed in the plasma to clindamycin. It has the same actions and uses as clindamycin hydrochloride, except that the...

May 5, 2024 · The results of our study show that we synthesized clindamycin propionate derivatives and clindamycin homo/heterodimer derivatives, which exhibited superior …

To improve taste properties, a series of 2- and 3- monoesters and some 2,3-dicarbonate esters of clindamycin were synthesized. A number of highly water-soluble salts were prepared in an …

Oct 1, 2000 · A novel synthesis of clindamycin from lincomycin using N-chlorosuccinimide and triphenylphosphine is reported. This results in high yields and avoids the use of …

Jun 1, 2017 · Clindamycin inhibits protein synthesis and acts specifically on the 50S subunit of the bacterial ribosome by affecting the process of peptide chain initiation, and may also stimulate …

Our research aims to reduce the bacterial resistance of clindamycin against Gram-positive bacteria and expand its range of bacterial susceptibility. First, we optimized the structure of …