Nov 2, 2010 · Here, we use a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework. We...

May 15, 2024 · Find sickle cell disease-related data and statistics on prevalence, complications, and more.

Map showing published Sickle Cell Disease (SCD) registries and database. Please refer to [ref] for more information. All SCD researchers are invited to share metadata regarding the phenotypes (published or unpublished) being collected.

Aug 1, 2023 · Completed as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, this study delivers a comprehensive global assessment of prevalence of sickle cell disease and mortality burden by age and sex for 204 countries and territories from 2000 to …

Nov 4, 2010 · In a study funded by the Wellcome Trust, geographers, biologists and statisticians at the University of Oxford, together with colleagues from the KEMRI-Wellcome Trust Research Programme in Kenya, have produced the first detailed global map showing the distribution of the sickle-cell gene.

Here, we use a comprehensive data assembly of HbS allele frequencies to generate the first evidence-based map of the worldwide distribution of the gene in a Bayesian geostatistical framework. We compare this map with the pre-intervention distribution of malaria endemicity, using a novel geostatistical area-mean comparison.

Nov 2, 2010 · In a study funded by the Wellcome Trust, geographers, biologists and statisticians at the University of Oxford, together with colleagues from the KEMRI-Wellcome Trust Research Programme in Kenya, have produced the first detailed global map showing the distribution of the sickle-cell gene.

At a global scale, the sickle cell gene is most commonly found in areas with historically high levels of malaria, adding geographical support to the hyphothesis that the gene, whilst potentially deadly, avoids disappearing through natural selection by providing protection against malaria.

Globally, there are more carriers (i.e. healthy people who have inherited only one mutant gene from one parent) of thalassaemia than of sickle-cell anaemia, but the high frequency of the sickle-cell gene in certain areas leads to a high rate of affected newborns.

Nov 2, 2010 · At a global scale, the sickle cell gene is most commonly found in areas with historically high levels of malaria, adding geographical support to the hypothesis that the gene, while potentially...