α-Amanitin (alpha-Amanitin) is a cyclic peptide of eight amino acids. It is possibly the most deadly of all the amatoxins, toxins found in several species of the mushroom genus Amanita, one being the death cap (Amanita phalloides) as well as the destroying angel, a complex of similar species, principally A. virosa and A. bisporigera.

Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The …

Alpha-Amanitin | C39H54N10O14S | CID 9543442 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Alpha-Amanitin is a toxic compound derived from the Amanita phalloides fungus, which inhibits mRNA synthesis in eukaryotic cells by binding to RNA polymerase II. It is commonly used in experimental biology due to its potent and selective action.

Alpha-amanitin (α-AMA) plays a major role in Amanita phalloides poisoning, showing toxic effects on multi-organs, particularly on the liver and kidneys. Studies have shown a relationship between α-AMA-related injuries and reactive oxygen species.

Alpha amanitin (α-AMA) is a toxin with hepatotoxic and nephrotoxic effects found in the content of Amanita phalloides-type mushrooms, causing serious poisoning with fatal outcomes. In the mechanism of toxicity, inhibition of protein synthesis by blocking RNA polymerase II in the liver plays an important role as well as oxidative stress and ...

Oct 21, 2022 · Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symptomatic and supportive therapy. The pathogenesis of α-amanitin mainly includes: α-amanitin can inhibit the activity of RNA polymeraseII in the nucleus, including the …

May 21, 2018 · α-Amanitin, along with its relatives β-, γ-, and ε-amanitin, are highly toxic cyclic peptides produced by species of the mushroom genus Amanita.The most notorious of these fungi is the so-called “death cap”, Amanita phalloides. α-Amanitin is considered to be the deadliest of the death-cap poisons.It has been estimated that A. phalloides accounts for 90% of mushroom …

Jan 1, 2024 · Amanitin’s cytotoxicity is brought on by inhibiting RNA polymerases, particularly RNA polymerase II, which prevents the production of mRNA. According to reports, humans are more sensitive to alpha-amanitin than rats. Usually, 6 to 24 h pass between ingesting the mushrooms and the appearance of symptoms.

Mar 21, 2018 · Mushroom-related toxins, alpha amanitin, and usage of antioxidants: Directions toward antioxidant capacity. 2021, 447-456. https://doi.org/10.1016/B978-0-12-819092-0.00044-3