Results: The results, derived from various research tools, strongly support the presence of a deficiency of the GABA system in MDD, which appears to be restored by common antidepressant treatments. More recent publications would indicate the complex interactions between GABA and all the other processes involved in MDD, such as monoamine ...

Deficits of GABA, combined with evidence that fluctuations of neuroactive steroids contribute to depression in women have led to development of GABAergic agents, including formulations of alloprenanolone (brexanolone and SAGE-217), which act as positive allosteric modulators of the GABA A R complex.

Increasing evidence points to an association between major depressive disorders (MDDs) and diverse types of GABAergic deficits. Here we summarize clinical and preclinical evidence supporting a central and causal role of GABAergic deficits in the etiology of depressive disorders.

Jun 26, 2023 · Decreased levels of GABA and NASs have been observed in adults with depression compared with healthy controls, while treatment with antidepressants normalized the altered levels of GABA and...

Network dysfunction in association with altered brain levels of glutamate (Glu) and gamma-aminobutyric acid (GABA) have been identified in both animal and human studies of depression.

Jan 1, 2012 · In view of the finding that anxiety disorders and major depression share a GABAergic deficit as a common pathophysiology, the GABA hypothesis of depression has found increasing support. It holds that α 2 /α 3 GABA A receptor modulators may serve as novel antidepressants.

In particular, it was reported that depression was accompanied by lower levels of GABA in cerebrospinal fluid (Sanacora and Saricicek, 2007) and based on neuroimaging analyses, GABA was reported to be reduced in the dorsolateral prefrontal and occipital cortex of depressed patients (Bhagwagar et al., 2007; Hasler et al., 2007; Price et al ...

Apr 3, 2019 · Chronic stress and depression are associated with reductions of both glutamate and GABA function, including atrophy of pyramidal neurons and reductions of glutamate and GABA neuronal markers in the medial PFC and hippocampus.

Nov 16, 2010 · Increasing evidence points to an association between major depressive disorders (MDDs) and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical evidence...

Mar 11, 2019 · Here, we provide further evidence supporting the role of cortical GABAergic interneurons, mainly somatostatin- and parvalbumin-expressing cells, required for the optimal E:I balance in the PFC and discuss how the malfunction of these cells can result in depression-related behaviors.