V(D)J recombination (variable–diversity–joining rearrangement) is the mechanism of somatic recombination that occurs only in developing lymphocytes during the early stages of T and B cell maturation.

Recent genomewide analyses of lymphoid neoplasms have revealed V(D)J recombination-driven oncogenic events, and have intensified interest in the regulatory mechanisms responsible for ensuring fidelity during V(D)J recombination.

V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA break and subsequent repair.

Apr 19, 2002 · V(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development.

Mar 11, 2011 · V(D)J recombination, which assembles antigen receptor genes during lymphocyte development, is initiated when the recombination activating gene 1 (RAG1) and RAG2 proteins bind and cleave...

Jul 11, 2018 · In this article, I will explain to you the structure of the antibody, the mechanism of VDJ recombination and the concept of antibody diversity. The present article will help you understand how immunological components will work effectively and how genetic mechanisms are involved in the process.

VDJ recombination is the process by which T cells and B cells randomly assemble different gene segments-known as variable (V), diversity (D), and joining (J) genes-in order to generate unique receptors (known as antigene receptors) that can collectively recognize many different types of …

This section briefly overviews the normal mechanism of V(D)J recombination (for more details, see references 8 and 9). The V(D)J recombinase recognizes conserved DNA sequence elements, termed recombination signal sequences (RSSs), located adjacent to each V, …

V(D)J recombination is a site-specific recombination reaction that occurs specifically in developing oocytes of vertebrates and plays a part in generating their vast repertoire of immunoglobulins and T-cell receptors.

Jan 23, 2004 · V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports—the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.